Opportunity Information: Apply for CDC RFA GH 23 0034

The grant opportunity titled "Strengthening Scale Up of HIV Prevention, Care and Treatment Programs in South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR)" is a CDC cooperative agreement (Funding Opportunity Number CDC RFA GH 23 0034; CFDA 93.067) intended to help South Sudan accelerate progress toward HIV epidemic control. While the listed award ceiling for Year 1 is shown as 0 (meaning no fixed per-award cap is specified in the notice), CDC anticipates an approximate total funding amount of $25,000,000 for the first fiscal year, contingent on funds being available, with an expectation of making about two awards. The opportunity is categorized as discretionary and is broadly open to eligible applicants without restriction, subject to any additional eligibility clarifications in the full notice.

The program rationale is grounded in South Sudan's fragile post-conflict context and the realities of a generalized HIV epidemic. The country is recovering from civil war and is implementing a revitalized peace agreement signed in 2018, but it continues to face sporadic conflict and major structural barriers that affect health service delivery. These include some of the lowest human development indicators globally, a weak and geographically dispersed health system, and limited infrastructure such as poor road networks that reduce access to care. Within this environment, adult HIV prevalence is estimated at 2.1%, and the total number of people living with HIV is estimated around 180,000. The opportunity reflects CDC South Sudan's intent, under PEPFAR, to support national efforts that concentrate resources in geographic areas with higher HIV burden in order to drive measurable population-level impact.

The notice emphasizes strong alignment and coordination with the Government of South Sudan, particularly the Ministry of Health, as well as with the Global Fund and other key partners already supporting the national response. Rather than operating in isolation, the funded work is designed to complement and strengthen existing platforms, fill operational gaps, and build longer-term capacity within government systems. A major feature of the award is that it blends direct service delivery with intensive capacity building and mentorship for the Ministry of Health at national, state, and county levels, reflecting the need to improve both immediate coverage and the sustainability of HIV services over time.

Programmatically, CDC outlines four core technical priorities. First is the expansion of HIV testing services through higher-yield approaches, meaning testing strategies that are more likely to identify people with undiagnosed HIV and link them quickly to care. Second is improving access to antiretroviral therapy services for the general population, explicitly including pregnant and breastfeeding women, which signals a strong focus on treatment scale-up and prevention of mother-to-child transmission outcomes. Third is improving viral load coverage and viral load suppression, highlighting the need not only to put people on treatment but also to ensure routine viral load monitoring and achieve suppression at scale, which is essential for individual health and reducing onward transmission. Fourth is advancing sustainable human resources for health, recognizing that South Sudan's HIV response is constrained by workforce shortages, skills gaps, and system capacity issues that require structured mentorship, training, and institutional strengthening.

Operationally, because this is a cooperative agreement, applicants should expect substantial involvement from CDC in program design refinement, performance monitoring, and coordination, consistent with how cooperative agreements typically function compared with standard grants. The goal is to implement a package of interventions that increases case finding in priority locations, improves treatment initiation and continuity, raises viral load testing coverage, drives viral suppression, and leaves behind stronger Ministry of Health capacity to manage, supervise, and sustain HIV programs. The application deadline for the original announcement was March 12, 2023, with electronic submissions due by 11:59 pm Eastern Time on the due date, and the opportunity was posted by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Center for Global Health.

  • The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Strengthening Scale Up of HIV Prevention, Care and Treatment Programs in South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
  • This funding opportunity was created on Jan 11, 2023.
  • Applicants must submit their applications by Mar 12, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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